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KMID : 0356919940270121740
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Korean Journal of Anesthesiology
1994 Volume.27 No. 12 p.1740 ~ p.1746
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The Priming Principle with Anticholinesterases for the Recovery of Profound Muscle Relaxation
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김교상
한정욱/민용진/전정우/이명의/전민선/나도준
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Abstract
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The success of accelerating the onset of neuromuscular blocking drugs by giving them in divided doses encouraged others to attempt the same "priming principle" using reversal agents. Naguib et al and Abdulatif et al demonstrated that the reversal
time
(time to reach a TOF of 0.75) was reduced when the reversal agent was administered in divided doses at T1 10% of control. But Donati et al and Szalados et al either could not detect any differences in the rate of reversal when anticholinesterases
were
administered in divided doses.
This study has been conducted to evaluate the reversal effects of neostigmine or pyridostigmine with priming principle in the rabbit after pancuronium injection when profound relaxation (PTC=0) was confirmed.
Rabbits (n=60) were randomly allocated to 4 groups. After pancuronium 0.2mg/kg Ⅳ, the onset and recovery times were evaluated. When the profound relaxation (PTC=0) was confirmed at 5min. after pancuronium injection, neostigmine 50μg/kg and
atropine
sulfate (atropine) 20μg/kg wre injected in group 1. At that time, neostigmine 10μg/kg and atropine 4μg/kg were injected and after 3min. neostigmine 40μg/kg and atropine 16μg/kg were injected in group 2. At that time, pyridostigmine 250μg/kg
and
atropine 20μg/kg were injected in group 3. At that time, pyridostigmine 50μg/kg and atropine 4μg/kg were injected and after 3min. pyridostigmine 200μg/kg and atropine 16μg/kg were injected in group 4.
@ES The results were as follows:
@EN 1) The time until 75% recovery of twitch amptitude was 53.1±12.4min. in group 1, 44.9±12.1min. in group 2, 54.9±9.7min. in group 3 and 48.2±7.1min. in group 4. The reversal times were tended to reduce when the reversal agents were
administered
with "priming principle" at the profound relaxation.
2) At he profound relaxation the reversal effects of neostigmine were greater thatn that of pyridostigmine.
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